Immunotoxin Treatment of Cancer*
نویسندگان
چکیده
منابع مشابه
Immunotoxin treatment of cancer.
Immunotoxins are proteins used to treat cancer that are composed of an antibody fragment linked to a toxin. The immunotoxin binds to a surface antigen on a cancer cell, enters the cell by endocytosis, and kills it. The most potent immunotoxins are made from bacterial and plant toxins. Refinements over many years have produced recombinant immunotoxins; these therapeutic proteins are made using p...
متن کاملImmunotoxin Therapy for Lung Cancer
introduction Lung cancer is the leading cause for cancer‐related deaths in both genders throughout the world. In the United States alone, there were 224,390 estimated new lung cancer cases and 158,080 estimated deaths in 2016.[1] As conventional chemotherapy has reached a plateau of effectiveness in lung cancers and fails in those tumors whose growth and metabolism can hardly be distinguished f...
متن کاملNew Life for Immunotoxin Cancer Therapy.
Immunotoxins are targeted anticancer therapeutics that kill cancer cells using a cytotoxic bacterial toxin payload. Their development for use in solid tumor malignancies was delayed due to issues with their immunogenicity and limited therapeutic window. However, new research has rejuvenated the field. Coadministration with a lymphocyte-depleting regimen of pentostatin and cyclophosphamide can d...
متن کاملRadioimmunotherapy-based treatment of cancer
The principle of cancer immunotherapy includes various methods of manipulations to influence immune responses against tumors in both humans and animals. This advanced technology of hybridoma production provided the necessary skills to efficiently produce highly specific monoclonal antibodies (mAb). Radioactively-tagged antibodies which are applied in radioimmunotherapy (RIT), can target adjacen...
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ژورنال
عنوان ژورنال: Annual Review of Medicine
سال: 2007
ISSN: 0066-4219,1545-326X
DOI: 10.1146/annurev.med.58.070605.115320